Structure–activity relationships of ustiloxin analogues
نویسندگان
چکیده
منابع مشابه
Enantioselective total synthesis of ustiloxin D.
Ustiloxin D and phomopsin A are potent antimitotic agents that bind to tubulin and interfere with cellular microtubule function. A synthetic strategy has been developed to allow access to both of the natural products as well as a variety of variants of the ustiloxin and phomopsin family members in order to provide sufficient quantities for biological studies. Herein we report the enantioselecti...
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15 صفحه اولSynthesis and anti-tubulin activity of ustiloxin D derivatives.
Ustiloxin D, produced by the rice plant pathogen Ustilaginoidea virens, exhibits potent anti-tubulin activity. In order to elucidate the effects of functional groups in ustiloxin D on its activity, several derivatives were synthesized and their anti-tubulin activities were estimated. The N,N-dimethylamino derivative and the 14-O-methyl derivative were inactive (IC50 > 50 microM). 20-Hydroxymeth...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2011
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.11.165